2:00 PM Steinman Hall, Room #312 (Chemical Engineering Conference Room)
“Food Supplementation within Liposomal Encapsulation Technology against Chronic Fatigue Syndrome” ABSTRACT Chronic Fatigue Syndrome (CFS) is an extremely debilitating sickness which lasts at least 6 months, accompanying sometimes the patient through the whole life1. Although the pathology of this disease is still unknown, many investigators nowadays focus their investigation on a possible disfunction of the mitochondria, as it is responsible of the 90 % of the human body energy production in form of ATP2,3. We have designed a combinatory therapy of coenzyme Q10, NADH, phosphatidylserine and vitamin C as a mitochondrial antioxidant therapy within the context of the liposomal encapsulation for oral administration. Homogeneous unilamellar liposomal suspension was developed by thin film hydration method 4-5 and characterized afterwards. Liposomes showed potential improvements on the bioavailability of drugs upon its oral administration, as demonstrated on in vitro experiments of stomach resistance at digestion and adhesion to intestinal mucosa. Also, ex vivo studies on porcine intestinal tissue exhibit an enhancement on the velocity rate of adsorption of the actives encapsulated within the liposomal technology. Additionally, the same liposomal active’s combinatory formula was developed and optimized to be produced within the context of microfluidics state-of-the-art technologies6-7, resulting in highly homogeneous GUV suspensions with an improvement on the encapsulation rate of the active ingredient Brief Academic/Employment History
Recent Research Interests Active encapsulation and delivery of drugs, new formulations to improve bioavailability of drugs.
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