Levich Institute Seminar Announcement, 11/05/2019 |
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Tuesday, 11/05/2019
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“Decoding Air/Liquid Interfaces using Synchrotron X-ray”
ABSTRACTIn this talk, I will be discussing the importance of surface sensitive synchrotron X-ray scattering techniques for three different systems. Synchrotron X-rays are commonly used as a tool for studying molecular scale phenomena at an air/water interface. Grazing incidence X-ray diffraction and X-ray reflectivity are applied to understand the interfacial structure at a molecular length scale. The former technique is well suited to determine the in-plane structure (xy-direction) of the Langmuir monolayers, while the latter technique predicts the contribution from all the species in the system in terms of the electron density profile normal to an interface (z-direction). The first part of the talk will focus on the adsorption behavior of monoclonal antibodies (mAbs) and surfactants competing for space at the air/water interface. Loss of mAbs at the air/water interface during drug formulations, storage, shipping and administration to the patients results in the decrease in efficacy and may promote immunogenicity. We have used X-ray reflectivity at the Advanced Photon Source (Sector 15-ID C), Argonne National Laboratory to understand the competitive adsorption of mAbs with surfactants. We will present our experimental and theoretical modeling of the systems, BRIEF ACADEMIC/EMPLOYMENT HISTORY:Ankit was born and raised in Mumbai, India. He received his BE in Chemical Engineering in 2016 from Institute of Chemical Technology, Mumbai, India and came to CCNY in the Fall of 2016. Ankit’s research is in collaboration with the Bristol-Myers Squibb Pharmaceutical Co., New Brunswick, NJ, and he is interested to continue in pharmaceuticals after his graduation.
MOST RECENT RESEARCH INTERESTS:Biomacromolecules at interfaces, protein aggregation and stability, interfacial science and engineering.
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